1982年毕业于中国科学技术大学，1986年在中国科学院大连化学物理研究所获博士学位；1986-1989年，意大利乌尔比诺大学和荷兰埃因德侯温理工大学博士后研究；1989年，回到中国科学院大连化学物理研究所，同年8月晋升为副研究员，1993.04晋升为研究员。1999年获国家杰出青年基金。2004年入选“新世纪百千万人才工程”国家级人选。2015年受聘为大连化物所首席研究员。曾任仪器分析化学研究室主任、所学术委员会委员。现任国家重点研发计划“海洋环境安全保障”重点专项总体专家组成员。中科院A类战略性先导专项“深海/深渊智能技术及海底原位科学实验站”总体专家组成员；中国仪器仪表学会会士、分析仪器分会名誉理事长，Journal of Chromatography A等杂志编委。

    主要研究方向包括微型色谱及仪器、弱光探测器、极端环境传感器、空间和深海探测仪器和传感器。主持国家科技部、国家自然科学基金、中科院等多项研究项目；已发表SCI论文190多篇，授权中国发明专利90余项，美国专利1项。培养毕业博士研究生36名，硕士研究生21名。

   曾获国家科技进步二等奖1项（排名第3），天津市科技进步一等奖2项（排名第2），辽宁省技术发明二等奖2项（排名第1），中科院自然科学二等奖1项（排名第1），大连市技术发明一等奖3项（排名第1）等多个奖项。

1. Lanxiu Ni, Shenghong Li, Kun Ding, Xuhui Geng, Chunfeng Duan, and Yafeng Guan*，Enhancement of Chemiluminescence Intensity of S2* in Non-premixed Hydrogen Microjet Flame in the Photometric Detector for Sulfur Detection. Analytical Chemistry, 2021, doi.org/10.1021/acs.analchem.0c02825.

2. Qiuying Xi1, Meng Shi1, Xuihui Geng*, Xiaona Wang*, Yafeng Guan*, Spherical dichroic reflector improves limit of detection in laser-induced fluorescence detection. Analytical Chemistry, 2020, 92(13), 8680-8684.

3. Meng Shi, Xuhui Geng*, Chengye Wang, Yafeng Guan*, Quantification of low copy number proteins in single cells. Analytical Chemistry, 2019, 91(18), 11493-11496.

4. Yuxuan Li1, Ting Deng1, Chunfeng Duan*, Lanxiu Ni, Nan Wang, Yafeng Guan*, Dispersive matrix solid-phase extraction method coupled with high performance liquid chromatography-tandem mass spectrometry for ultrasensitive quantification of endogenous brassinosteroids in minute plants and its application for geographical distribution study. Journal of Agricultural and Food Chemistry, 2019, 67(10), 3037-3045.

5. Nan Wang, Chunfeng Duan, Xuhui Geng, Shenghong Li, Kun Ding, Yafeng Guan*, One step rapid dispersive liquid-liquid micro-extraction with in-situ derivatization for determination of aflatoxins in vegetable oils based on high performance liquid chromatography fluorescence detection. Food Chemistry, 2019, 287, 333-337.

6. Ting Deng, Dapeng Wu, Chunfeng Duan, Xiaohui Yan, Yan Du, Jun Zou, Yafeng Guan*, Spatial Profiling of Gibberellins in a Single Leaf Based on Microscale Matrix Solid-Phase Dispersion and Precolumn Derivatization Coupled with Ultraperformance Liquid Chromatography-Tandem Mass Spectrometry. Analytical Chemistry, 2017, 89, 9537-9543.

7. Hu Meng，Wei Yang，Kun Ding，Liang Feng*，Yafeng Guan*. Cu2O nanorods modified by reduced graphene oxide for NH3 sensing at room temperature. Journal of Materials Chemistry A, 2015, 3, 1174-1181.

8. Hu Meng, Wei Yang, Xiaohui Yan, Yanggang Zhang, Liang Feng*, Yafeng Guan*, A highly sensitive and fast responsive semiconductor metal oxide detector based on In2O3 nanoparticle film for portable gas chromatograph. Sensors and Actuators B: Chemical, 2015, 216, 511-517.

9. Qian Wu, Dapeng Wu*, Yafeng Guan*, Hybrid Titania–Zirconia Nanoparticles Coated Adsorbent for Highly Selective Capture of Nucleosides from Human Urine in Physiological Condition. Analytical Chemistry, 2014, 86(20), 10122-10130.

10. Qian Wu, Dapeng Wu*, Yafeng Guan*, In Vivo Fast Equilibrium Microextraction by Stable and Biocompatible Nanofiber Membrane Sandwiched in Microfluidic Device. Analytical Chemistry, 2013, 85(23), 11524-11531.

11. Qian Wu, Dapeng Wu*, Yafeng Guan*, Fast Equilibrium Micro-Extraction from Biological Fluids with Biocompatible Core-Sheath Electrospun Nanofibers. Analytical Chemistry, 2013, 85(12), 5924-5932.

12. Weiwei Li, Yafeng Guan*, Zheng Shen, Dapeng Wu, A surface ionization detector for capillary gas chromatography. Chemical Communications., 2011, 47, 2423-2425.