人才队伍
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人才信息
姓名:
 赵宗保
性别:
 男
类别:
 研究员;杰青;百人
学科:
 生物化工
职称:
 研究员
学历:
 博士研究生
电话:
 0411-84379211
Email:
 zhaozb@dicp.ac.cn
地址:
 大连市中山路457号
邮编:
 116023
简历介绍:

  赵宗保,男,1968年生。研究员,博士生导师,大连化物所生物质高效转化组组长。中国科学院百人计划入选者。国家杰出青年科学基金获得者。中国可再生能源学会生物质能专业委员会理事,中国化学会化学生物学专业委员会委员,中国化工学会离子液体专业委员会委员。大连市归国留学人员创业英才,市劳动模范。1990年、1995年先后在湖南师范大学化学系获理学学士学位和硕士学位。1998年在中科院上海有机化学研究所获理学博士学位,专业有机合成1998年至2003年先后在美国明尼苏达大学和德克萨斯大学奧斯汀分校从事博士后研究,方向为生物有机化学和代谢工程。200311月应聘到中科院大连化物所生物技术部工作,从事能源生物技术、分子微生物学和化学生物学研究。已发表论文150余篇,申请专利50余件。 

代表论著:

  1. Gong ZW, Wang Q, Shen HW, Xie HB, Zhao ZK. “Conversion of biomass-derived oligosaccharides into lipids” Biotechnol. Biofuels 2014, 7, 13.

  2. Wang KY, Zhou YJ, Liu HW, Cheng K, Mao JW, Wang FJ, Liu WJ, Ye ML, Zhao ZK, Zou HF. “Proteomic analysis of protein methylation in the yeast Saccharomyces cerevisiae” J Prot. 2014, doi: 10.1016/j.jprot.2014.07.032.

  3. Lin XP, Wang YN, Zhang SF, Zhu ZW, Zhou YJ, Yang F, Sun WY, Wang XY, Zhao ZK. “Functional integration of multiple genes into the genome of the oleaginous yeast Rhodosporidium toruloides” FEMS Yeast Res. 2014, 14(6), 547–555.

  4. Guo J, Zhou YJ, Hillwig ML, Shen Y, Yang L, Wang YJ, Zhang XN, Liu WJ, Peters RJ, Chen XY, Zhao ZK, Huang LQ. “CYP76AH1 catalyzes turnover of miltiradiene in tanshinones biosynthesis and enables heterologous production of ferruginol in yeasts” Proc. Natl. Acad. Sci. USA 2013, 110(29), 12108–12113.

  5. Gong ZW, Shen HW, Wang Q, Yang XB, Zhao ZK. “Efficient conversion of biomass into lipids by using the simultaneous saccharification and enhanced lipid production process” Biotechnol. Biofuels 2013, 6, 36.

  6. Zhang YX, Pan YB, Yang W, Liu WJ, Zou HF, Zhao ZK. “Protein arginine allylation and subsequent fluorophore targeting” ChemBioChem 2013, 14(12), 1438–1443.

  7. Ji DB, Wang L, Liu WJ, Hou SH, Zhao ZK. “Synthesis of NAD analogs to develop bioorthogonal redox system” Sci. Chin. Chem. 2013, 56(3), 296–300.

  8. Zhu ZW, Zhang SF, Liu HW, Shen HW, Lin XP, Yang F, Zhou YJ, Jin GJ, Ye ML, Zou HF, Zhao ZK. “A multi-omic map of the lipid-producing yeast Rhodosporidium toruloides” Nat. Commun. 2012, 3, 1112.

  9. Zhou YJ, Gao W, Rong QX, Jin GJ, Chu HY, Liu WJ, Yang W, Zhu ZW, Li GH, Zhu GF, Huang LQ, Zhao ZK. “Modular pathway engineering of diterpenoid synthases and the mevalonic acid pathway for miltiradiene production” J. Am. Chem. Soc. 2012, 134(6), 3234–3241.

  10. Xie HB, Shen HW, Gong ZW, Wang Q, Zhao ZK, Bai FW. “Enzymatic hydrolysates of corn stover pretreated by the N-methylpyrrolidone/ionic liquids solution for microbial lipid production” Green Chem. 2012, 14(4), 1202–1210.

  11. Jin GJ, Yang F, Hu CM, Shen HW, Zhao ZK. “Enzyme-assisted extraction of lipids directly from the culture of the oleaginous yeast Rhodosporidium toruloides” Bioresour. Technol. 2012, 111(1), 378–382.

  12. Ji DB, Wang L, Hou SH, Liu WJ, Wang JX, Wang Q, Zhao ZK. “Creation of bioorthogonal redox systems depending on nicotinamide flucytosine dinucleotide” J. Am. Chem. Soc. 2011, 133(51), 20857–20862.

  13. Hu CM, Wu SG, Wang Q, Jin GJ, Shen HW, Zhao ZK. “Simultaneous utilization of glucose and xylose for lipid production by Trichosporon cutaneum” Biotechnol. Biofuels 2011, 4, 25.

  14. Zhou YJ, Wang L, Yang F, Lin XP, Zhang SF, Zhao ZK. “Determining the extremes of the cellular NAD(H) level by using an Escherichia coli NAD+-auxotrophic mutant” Appl. Environ. Microbiol. 2011, 77(17), 6133–6140.

  15. Wu SG, Hu CM, Jin GJ, Zhao X, Zhao ZK. “Phosphate-limitation mediated lipid production by Rhodosporidium toruloides” Bioresour. Technol. 2010, 101(15), 6124–6129.

  16. Zhang ZH, Zhao ZK. “Microwave-assisted conversion of lignocellulosic biomass into furans in ionic liquid” Bioresour. Technol. 2010, 101(3), 1111–1114.

  17. Li CZ, Zhang ZH, Zhao ZK. “Direct conversion of glucose and cellulose to 5-hydroxymethylfurfural in ionic liquid under microwave irradiation” Tetrahedron Lett. 2009, 50(38), 5403–5405.

  18. Liu WJ, Wu SG, Hou SH, Zhao ZK. “Synthesis of phosphodiester-type nicotinamide adenine dinucleotide analogs” Tetrahedron 2009, 65(40), 8378–8383.

  19. Tian RJ, Li LD, Tang W, Liu HW, Ye ML, Zhao ZK, Zou HF. “Chemical proteomic study of isoprenoid chain interactome with a synthetic photoaffinity probe” Proteomics, 2008, 8(15), 3094–3104.

  20. Li CZ, Wang Q, Zhao ZK. “Acid in ionic liquid: An efficient system for hydrolysis of lignocellulose” Green Chem. 2008, 10(2), 177–182.

  21. Hong L, Zhao ZB, Melancon CE, Zhang H, Liu H-w. “In vitro characterization of the enzymes involved in TDP-D-forosamine biosynthesis in the spinosyn pathway of Saccharopolyspora spinosa” J. Am. Chem. Soc. 2008, 130(14), 4954–4967.

  22. Xiao YL, Zhao ZB, Liu PH. “Mechanistic studies of IspH in the deoxyxylulose phosphate pathway: Heterolytic C-O bond cleavage at C4 position” J. Am. Chem. Soc. 2008, 130(7), 2164–2165.

  23. Li YH, Zhao ZK, Bai FW. “High-density cultivation of oleaginous yeast Rhodosporidium toruloides Y4 in fed-batch culture” Enzyme Microb. Technol. 2007, 41(3), 312–317.

  24. Hong L, Zhao ZB, Liu H-w. “Characterization of SpnQ from the spinosyn biosynthetic pathway of Saccharopolyspora spinosa: Mechanistic and evolutionary implications for C-3 deoxygenation in deoxysugar biosynthesis” J. Am. Chem. Soc. 2006, 128(44), 14262–14263.

  25. Zhao ZB, Hong L, Liu H-w. “Characterization of protein encoded by spnR from the spinosyn gene cluster of Saccharopolyspora spinosa: Mechanistic implications for forosamine biosynthesis” J. Am. Chem. Soc. 2005, 127(21), 7692–7693.

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