1) New approaches for analysis of protein post-translational modifications
2) Mass spectrometry-based approach for identification and quantification of proteins
3) New proteomics approaches to screen drug targets
（1）Winner for the National Science Fund of China for Distinguished Young Scholars
1.Jiawen Lyu, Chengfei Ruan, Xiaolei Zhang, Yan Wang, Kejia Li, Mingliang Ye*, Microparticle-Assisted Precipitation Screening Method for Robust Drug Target Identification. Anal. Chem., 2020, 92, 13912-13921
2.Jiawen Lyu, Keyun Wang, Mingliang Ye*, Modification-free approaches to screen drug targets at proteome level, Trac Anal. Chem., 2020, 124, 115574
3.Xin You, Yating Yao, Jiawei Mao, Hongqiang Qin, Xinmiao Liang, Liming Wang, Mingliang Ye*. Chemoenzymatic Approach for the Proteomics Analysis of Mucin- Type Core?1 O?Glycosylation in Human Serum. Anal. Chem., 2018, 90, 12714?12722
4.Zhenzhen Deng, Jiawei Mao, Yan Wang, Hanfa Zou, Mingliang Ye*. Enzyme kinetics for complex system enables accurate determination of specificity constants of numerous substrates in a mixture by proteomics platform. Mol. Cell. Proteomics, 2017, 16(1), 135-145
5.Yangyang Bian, Lei Li, Mingming Dong, Xuguang Liu, Tomonori Kaneko, Kai Cheng, Huadong Liu, Courtney Voss, Xuan Cao, Yan Wang, David Litchfield, Mingliang Ye*, Shawn SC Li*, Hanfa Zou*. Ultra-deep tyrosine phosphoproteomics enabled by a phosphotyrosine superbinder. Nat. Chem. Biol., 2016, 12, 959-968
