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   Yukui Zhang
Title: Professor, Group 1810
Subject: Analytical Chemistry
Phone: 0411-84379560
Email: ykzhang@dicp.ac.cn
Website: http://www.proteomics.dicp.ac.cn/faculty/zhangyukui_en.htm
Address: 457 Zhongshan Road,Dalian,China,116023
Resume:

Prof. Yukui Zhang is the member of Chinese Academy of Sciences, and Research professor of Dalian Institute of Chemical Physics (DICP), Chinese Academy of Sciences (CAS).

He obtained his B.S. from Nankai University in 1965, and after that he has been working in DICP, CAS. He worked as the duty director and the director of National Chromatographic R. & A. Center in 1990s. Now he is the expert member for National Key Research Project of Proteins. He is also the duty director-general of China Association for Instrumental Analysis, and the director of Chromatography Branch of Chinese Chemistry Society. He is now an editorial board member of Anal. Chem..

Prof. Zhang’s research is focused on the fundamental, new techniques and methods for chromatography. He developed systematic thermodynamic and kinetic research methods for chromatography, and made great contribution to the establishment of expert systems for liquid chromatography. In capillary electrophoresis field, he found the rules by studying the effect of operation parameters and molecular structure of solutes on the migration, and was one of the pioneer researchers in capillary electrochromatography in China. In recent study, with the consideration of great requirements put forward by important application fields, he has been working on the development of new techniques for both qualitative and quantitative proteome study.

Prof. Zhang has published over 500 papers, written 7 books and applied more than 50 patents. He also has brought up over 30 Ph.D. students. Some of them are promoted to professors now, and some are the elites in instrumental companies, who are playing important roles in fundamental study, application and developments, as well as industrialization in analytical chemistry fields.

Research interests:

High efficient separation and characterization of complex samples

Projects undertaken:

Research on multidimensional biochromatography and the key units of liquid chromatography-mass spectrometry (National key scientific instrument and equipment development projects, MOST)

Theoretic study on highly sensitive ESI source and applications in the analysis of low abundance proteins (Major project of National Natural Science Foundation)

Time 

Honors and Awards 

2012 

Second Prize of the National Natural Science Award 

2011 

First Prize of the Natural Science Award of Liaoning Province 

2004 

First Prize of the Natural Science Award of Liaoning Province 

2001 

First Prize of the Natural Science Award of Liaoning Province 

2001 

Second Prize of Scientific and Technological Achievements of Liaoning Province 

1. Bo Jiang, Yu Liang, Qi Wu, Hao Jiang, Kaiguang Yang, Lihua Zhang*, Zhen Liang, Xiaojun Peng, Yukui Zhang, New GO-PEI-Au-L-Cys ZIC-HILIC, composites: synthesie and selective enrichment of glycopeptides, Nanoscale, 2014, 6: 5616-5619.

2. Jianxi Liu, Yanyan Qu, Kaiguang Yang, Qi Wu, Yichu Shan, Lihua Zhang*, Zhen Liang, Yukui Zhang, Monodisperse Boronate Polymeric Particles Synthesized by a Precipitation Polymerization Strategy: Particle Formation and Glycoprotein Response from the Standpoint of the Flory-Huggins Model, Acs Applied Materials & Interfaces, 2014, 6: 2059-2066.

3. Qun Zhao, Yu Liang, Huiming Yuan, Zhigang Sui, Qi Wu, Zhen Liang, Lihua Zhang*, Yukui Zhang, Biphasic Microreactor for Efficient Membrane Protein Pretreatment with a Combination of Formic Acid Assisted Solubilization, On-Column pH Adjustment, Reduction, Alkylation, and Tryptic Digestion, Analytical Chemistry, 2013, 85, 8507-8512.

4. Yuan Zhou, Yichu Shan, Qi Wu, Shen Zhang, Lihua Zhang*, Yukui Zhang, Mass Defect-Based Pseudo-Isobaric Dimethyl Labeling for Proteome Quantification, Analytical Chemistry, 2013, 85, 10658-10663.

5. Qun Zhao, Yu Liang, Huiming Yuan, Zhigang Sui, Qi Wu, Zhen Liang, Lihua Zhang*, Yukui Zhang, Biphasic Microreactor for Efficient Membrane Protein Pretreatment with a Combination of Formic Acid Assisted Solubilization, On-Column pH Adjustment, Reduction, Alkylation, and Tryptic Digestion, Analytical Chemistry, 2013, 85, 8507-8512.

6. Yuan Zhou, Yichu Shan, Qi Wu, Shen Zhang, Lihua Zhang*, Yukui Zhang, Mass Defect-Based Pseudo-Isobaric Dimethyl Labeling for Proteome Quantification, Analytical Chemistry, 2013, 85, 10658-10663.

7. Liyuan Zhang, Qun Zhao, Zhen Liang, Yang Kaiguang, Sun Liangliang, Lihua Zhang*, Yukui Zhang, Synthesis of adenosine functionalized metal immobilized magnetic nanoparticles for highly selective and sensitive enrichment of phosphopeptides, Chemical Communications, 2012, 48(50): 6274-6276.

8. Yanan Qu, Jianxi Liu, Kaiguang Yang, Zhen Liang, Lihua Zhang*, Yukui Zhang, Boronic Acid Functionalized Core-Shell Polymer Nanoparticles Prepared by Distillation Precipitation Polymerization for Glycopeptide Enrichment, Chemistry-a European Journal, 2012, 18(29): 9056-9062.

9. Huiming Yuan, Yuan Zhou, Simin Xia, Lihua Zhang*, Xiaodan Zhang, Qi Wu, Zhen Liang, Yukui Zhang, Integrated Platform for Proteome Profiling with Combination of Microreversed Phase Based Protein and Peptide Separation via Online Solvent Exchange and Protein Digestion, Analytical Chemistry, 2012, 84(11): 5124-5132.

10. Junfeng Ma, Lihua Zhang*, Zhen Liang, Yichu Shan, Yukui Zhang, Immobilized enzyme reactors in proteomics, Trac-Trends in Analytical Chemistry, 2011, 30(5), 691-702.

11. Yanyan Qu, Simin Xia, Huiming Yuan, Qi Wu, Man Li, Lijuan Zou, Lihua Zhang*, Zhen Liang, Yukui Zhang, Integrated Sample Pretreatment System for N-Linked Glycosylation Site Profiling with Combination of Hydrophilic Interaction Chromatography and PNGase F Immobilized Enzymatic Reactor via a Strong Cation Exchange Precolumn, Analytical Chemistry, 2011, 83(19), 7457-7463.

12. Jinxiang Liu, Kaiguang Yang, Qiliang Deng, Qinran Li, Lihua Zhang*, Zhen Liang, Yukui Zhang, Preparation of a new type of affinity materials combining metal coordination with molecular imprinting, Chemical Communications, 2011, 47(13), 3969-3971.

13. Liangliang Sun, Jun Ma, Xiaoqiang Sun, Dingyin Tao, Yanyan Zhang, Yichu Shan, Zhen Liang, Lihua Zhang*, Yukui Zhang, Intergrated Device for Online Sample Buffer Exchange, Protein Enrichment, and Digestion, Analytical Chemistry, 2010, 82(6), 2574-2579.

14. Junfeng Ma, Chunyan Hou, Liangliang Sun, Dingyin Tao, Yanyan Zhang, Yichu Shan, Zhen Liang, Lihua Zhang* , Ling Yang, Yukui Zhang, Coupling Formic Acid Assisted Solubilization and online Immobi-lized Pepsin Microreactor Digestion with SCX-μPRLC-ESI-MS/MS for Integral Membrane Proteome Analysis, Analytical Chemistry, 2010, 82, 9622-9625.

15. Huiming Yuan, Lihua Zhang*, Chunyan Hou, Guijie Zhu, Dingyin Tao, Zhen Liang, Yukui Zhang, Integrated platform for proteome analysis with combination of protein and peptide separation via online digestion, Analytical Chemistry, 2009, 81(21), 8708-8714.

16. Junfeng Ma, Jinxiang Liu, Liangliang Sun, Liang Gao, Zhen Liang, Lihua Zhang*, Yukui zhang, Online Integration of Multiple Sample Pretreatment Steps Involving Denaturation, Reduction, and Digestion with Microflow Reversed-Phase Liquid Chromatography-Electrospray Ionization Tandem Mass Spectrometry for High-Throughput Proteome Profiling, Analytical Chemistry, 2009, (81) 6534-6540.

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